Common Functional Deficits in MCI and Dementia 

 
   Lead Investigator:    Patrick Brown
   Institution      :    Columbia
   E-Mail           :    pb2410@columbia.edu
   Proposal ID      :    371


   Publications:


1  Brown P
   Targeting Dopaminergic Mechanisms of Slowing to Improve Late Life Depression
   42461   Grant  NIMH   R61MH110029   , 

   FUNDED



2  Brown PJ, Liu X, Sneed JR, Pimontel MA, Devanand DP, Roose SP
   Speed of processing and depression affect function in older adults with mild cognitive impairment
   Journal Article  Am J Geriatr Psychiatry,21:675-684,2013,PMC3410965

   PUBLISHED



3  Brown PJ, Sneed JR, Rutherford B, Devanand DP, Roose SP
   The nuances of cognition and depression in older adults: the need for a comprehensive assessment
   Journal Article  Int J Geriatr Psychiatry,29:506-514,2014,PMC3975802

   PUBLISHED



4  Devanand DP, Liu X, Brown P
   Impact of Functional Deficits in Mild Cognitive Impairment: A Clinical Algorithm to Predict Progression to Dementia
   Abstract  Alzheimers Dement,12:P393-P394,2016,

   PUBLISHED



5  Devanand DP, Liu X, Brown PJ
   Impact of Functional Deficits in Instrumental Activities of Daily Living in Mild Cognitive Impairment: A Clinical Algorithm to Predict Progression to Dementia
   Journal Article  Alzheimer Dis Assoc Disord,1:55-61,2017,PMC5321859

   PUBLISHED





   Proposal Description:
   The loss of functional abilities for those individuals with cognitive impairment is a progressive process that is part of a larger degeneration that occurs with illnesses such as dementia and more specifically, Alzheimer's disease. Although Mild Cognitive Impairment, a term used to identify the intermediate phase between cognitively normal and demented older adults, was believed to be a phase with intact daily functioning, research has shown subtle deficits in instrumental activities of daily living illustrating that functional deficits are early markers for cognitive degeneration. Because of the effect that functional deficits in everyday living can have, it is imperative that its role in the dementia process be better understood: What are the most prevalent functional deficits that mark that earliest stages of cognitive impairment and do these deficits predict conversion to dementia? To begin to address these issues, the proposed study has three goals: 1. To identify a subset of deficits in everyday functioning that differentiates cognitively intact healthy older controls from older adults with cognitive impairment, 2. To evaluate over a four-year follow-up period if this subset of functional impairments predicts cognitive and functional decline and conversion to dementia, and 3. Promote earlier identification of clinically relevant symptomatology, thereby allowing for the development and future implementation of tailored treatments designed to maintain time living independently, resulting in higher quality of life for patients with cognitive impairment.